Chronic inflammation and oxidative stress: The smoking gun for Helicobacter pylori-induced gastric cancer?

DM Hardbower, T de Sablet, R Chaturvedi… - Gut microbes, 2013 - Taylor & Francis
Helicobacter pylori is the leading risk factor associated with gastric carcinogenesis. H. pylori
leads to chronic inflammation because of the failure of the host to eradicate the infection …

Human and Helicobacter pylori coevolution shapes the risk of gastric disease

N Kodaman, A Pazos, BG Schneider… - Proceedings of the …, 2014 - National Acad Sciences
Helicobacter pylori is the principal cause of gastric cancer, the second leading cause of
cancer mortality worldwide. However, H. pylori prevalence generally does not predict cancer …

Spermine oxidase mediates the gastric cancer risk associated with Helicobacter pylori CagA

R Chaturvedi, M Asim, J Romero–Gallo, DP Barry… - Gastroenterology, 2011 - Elsevier
BACKGROUND & AIMS: Helicobacter pylori–induced gastric carcinogenesis has been
linked to the microbial oncoprotein cytotoxin-associated gene A (CagA). Spermine oxidase …

Phylogeographic origin of Helicobacter pylori is a determinant of gastric cancer risk

T de Sablet, MB Piazuelo, CL Shaffer, BG Schneider… - Gut, 2011 - gut.bmj.com
Background and aims Helicobacter pylori colonises the stomach in half of all humans, and is
the principal cause of gastric cancer, the second leading cause of cancer death worldwide …

Arginine and polyamines in Helicobacter pylori-induced immune dysregulation and gastric carcinogenesis

R Chaturvedi, T De Sablet, LA Coburn, AP Gobert… - Amino acids, 2012 - Springer
Abstract l-arginine (l-Arg) is metabolized by nitric oxide synthase and arginase enzymes.
The gastric pathogen Helicobacter pylori causes peptic ulcer disease and gastric cancer …

Spermine oxidase, a polyamine catabolic enzyme that links Helicobacter pylori CagA and gastric cancer risk

R Chaturvedi, T de Sablet, RM Peek Jr, KT Wilson - Gut microbes, 2012 - Taylor & Francis
We have recently reported that Helicobacter pylori strains expressing the virulence factor
cytotoxin-associated gene A (CagA) stimulate increased levels of spermine oxidase (SMO) …

Human Microbiota-Secreted Factors Inhibit Shiga Toxin Synthesis by Enterohemorrhagic Escherichia coli O157:H7

T De Sablet, C Chassard… - Infection and …, 2009 - Am Soc Microbiol
Escherichia coli O157: H7 is a food-borne pathogen causing hemorrhagic colitis and
hemolytic-uremic syndrome, especially in children. The main virulence factor responsible for …

Increased Helicobacter pylori-associated gastric cancer risk in the Andean region of Colombia is mediated by spermine oxidase

R Chaturvedi, T de Sablet, M Asim, MB Piazuelo… - Oncogene, 2015 - nature.com
Helicobacter pylori infection causes gastric cancer, the third leading cause of cancer death
worldwide. More than half of the world's population is infected, making universal eradication …

Arginase II restricts host defense to Helicobacter pylori by attenuating inducible nitric oxide synthase translation in macrophages

ND Lewis, M Asim, DP Barry, K Singh… - The Journal of …, 2010 - journals.aai.org
Helicobacter pylori infection of the stomach causes peptic ulcer disease and gastric cancer.
Despite eliciting a vigorous immune response, the bacterium persists for the life of the host …

Polyamines impair immunity to Helicobacter pylori by inhibiting L-arginine uptake required for nitric oxide production

R Chaturvedi, M Asim, S Hoge, ND Lewis, K Singh… - Gastroenterology, 2010 - Elsevier
BACKGROUND & AIMS: Helicobacter pylori–induced immune responses fail to eradicate
the bacterium. Nitric oxide (NO) can kill H pylori. However, translation of inducible NO …