Oncogene-induced senescence (OIS) is crucial for tumour suppression. Senescent cells
implement a complex pro-inflammatory response termed the senescence-associated …

INTRODUCTION Primary liver tumors and liver metastasis currently represent the leading
cause of cancer-related deaths. The liver intimately cross-talks with the gut and performs …

Upon the aberrant activation of oncogenes, normal cells can enter the cellular senescence
program, a state of stable cell-cycle arrest, which represents an important barrier against …

Hepatitis C virus (HCV) is a major causative agent of chronic liver disease in humans. To
gain insight into host factor requirements for HCV replication, we performed a siRNA screen …

Hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) is responsible for persistent
infection of hepatocytes. The aim of this study was to determine changes in intrahepatic …

Oncogene-induced senescence causes hepatocytes to secrete cytokines, which induce their
immune-mediated clearance to prevent tumor initiation, a process termed" senescence …

Macrophages are key regulators of liver fibrosis progression and regression in nonalcoholic
steatohepatitis (NASH). Liver macrophages comprise resident phagocytes, Kupffer cells …

Primary liver cancer represents a major health problem. It comprises hepatocellular
carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC), which differ markedly with …

Abstract The 2005 National Institute of Health (NIH) Consensus Conference outlined
histopathological diagnostic criteria for the major organ systems affected by both acute and …

In solid tumors, resistance to therapy inevitably develops upon treatment with cytotoxic drugs
or molecularly targeted therapies. Here, we describe a system that enables pooled shRNA …