The intestinal microbiota fuelling metabolic inflammation

H Tilg, N Zmora, TE Adolph, E Elinav - Nature Reviews Immunology, 2020 - nature.com
Low-grade inflammation is the hallmark of metabolic disorders such as obesity, type 2
diabetes and nonalcoholic fatty liver disease. Emerging evidence indicates that these …

Gut-liver axis: Pathophysiological concepts and clinical implications

H Tilg, TE Adolph, M Trauner - Cell Metabolism, 2022 - cell.com
Bidirectional crosstalk along the gut-liver axis controls gastrointestinal health and disease
and exploits environmental and host mediators. Nutrients, microbial antigens, metabolites …

[PDF][PDF] The intestinal microbiota in colorectal cancer

H Tilg, TE Adolph, RR Gerner, AR Moschen - Cancer cell, 2018 - cell.com
Experimental evidence from the past years highlights a key role for the intestinal microbiota
in inflammatory and malignant gastrointestinal diseases. Diet exhibits a strong impact on …

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif… - autophagy, 2021 - Taylor & Francis
In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Paneth cells as a site of origin for intestinal inflammation

TE Adolph, MF Tomczak, L Niederreiter, HJ Ko, J Böck… - Nature, 2013 - nature.com
The recognition of autophagy related 16-like 1 (ATG16L1) as a genetic risk factor has
exposed the critical role of autophagy in Crohn's disease. Homozygosity for the highly …

Non-alcoholic fatty liver disease: the interplay between metabolism, microbes and immunity

H Tilg, TE Adolph, M Dudek, P Knolle - Nature metabolism, 2021 - nature.com
Non-alcoholic fatty liver disease (NAFLD) has emerged pandemically across the globe and
particularly affects patients with obesity and type 2 diabetes. NAFLD is a complex systemic …

Calprotectin: from biomarker to biological function

A Jukic, L Bakiri, EF Wagner, H Tilg, TE Adolph - Gut, 2021 - gut.bmj.com
The incidence of inflammatory bowel diseases (IBD) emerged with Westernisation of dietary
habits worldwide. Crohn's disease and ulcerative colitis are chronic debilitating conditions …

Recovery of ethanol-induced Akkermansia muciniphila depletion ameliorates alcoholic liver disease

C Grander, TE Adolph, V Wieser, P Lowe, L Wrzosek… - Gut, 2018 - gut.bmj.com
Objective Alcoholic liver disease (ALD) is a global health problem with limited therapeutic
options. Intestinal barrier integrity and the microbiota modulate susceptibility to ALD …

Postacute COVID-19 is characterized by gut viral antigen persistence in inflammatory bowel diseases

A Zollner, R Koch, A Jukic, A Pfister, M Meyer… - Gastroenterology, 2022 - Elsevier
Background & Aims The coronavirus disease 2019 (COVID-19) pandemic has affected
populations, societies, and lives for more than 2 years. Long-term sequelae of COVID-19 …

[HTML][HTML] Multiple parallel hits hypothesis in nonalcoholic fatty liver disease: revisited after a decade

H Tilg, TE Adolph, AR Moschen - Hepatology, 2021 - journals.lww.com
Nonalcoholic fatty liver disease (NAFLD) is an epidemic liver disease, affecting
approximately one quarter of the entire population in the world.(1) This disease …