CCX282-B, also called vercirnon, is a specific, orally-administered chemokine receptor
CCR9 antagonist that regulates migration and activation of inflammatory cells in the …

Objective: The infliximab biosimilar CT-P13 (Remsima®, Inflectra®) was approved in Europe
for the treatment of inflammatory bowel disease (IBD) based on extrapolation of data from …

Abstract Background and Aims Ontamalimab, a fully-human monoclonal antibody targeting
MAdCAM-1, induced remission in patients with moderate-to-severe ulcerative colitis [UC] in …

Objective To evaluate the cost-effectiveness of an inflammatory biomarker and clinical
symptom directed tight control strategy (TC) compared with symptom-based clinical …

Liver cirrhosis is the most common reason of clinically significant portal hypertension in the
western countries. Portal vein or hepatic veins thrombosis is less common. Variceal …

Methods: The probiotic was administered to 7 patients and placebo to 15. The study was
discontinued early following the release of the Propatria study results. Results: There was no …

Farmakoterapie patří v medicíně stále mezi tzv. ars medici. V posledních letech jsme svědky
zavádění a využívání nových diagnostických metod v gastroenterologické praxi. Tyto nové …

Cholestasis is defined as hepatocyte and cholangiocyte bile excretion failure or failure of
bile transport to the duodenum. Primary biliary cholangitis (PBC) and primary sclerosing …

Mucosal healing (MH) has become a perspective treatment target in patients with Crohn's
disease (CD). Data about the impact of MH on long-term outcome in pediatric patients are …

Background Mucosal healing (MH) has become a perspective treatment target in patients
with Crohn's disease (CD). Data about the impact of MH on long-term outcome in pediatric …