Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer
…, JA Moral, R Remark, B Herbst, G Askan, U Bhanot… - Nature, 2017 - nature.com
Pancreatic ductal adenocarcinoma is a lethal cancer with fewer than 7% of patients
surviving past 5 years. T-cell immunity has been linked to the exceptional outcome of the few …
surviving past 5 years. T-cell immunity has been linked to the exceptional outcome of the few …
[PDF][PDF] Signatures of plasticity, metastasis, and immunosuppression in an atlas of human small cell lung cancer
Small cell lung cancer (SCLC) is an aggressive malignancy that includes subtypes defined
by differential expression of ASCL1, NEUROD1, and POU2F3 (SCLC-A,-N, and-P …
by differential expression of ASCL1, NEUROD1, and POU2F3 (SCLC-A,-N, and-P …
PIK3CA mutation associates with improved outcome in breast cancer
Purpose: In breast cancer, somatic mutations in the PIK3CA gene are common. The
prognostic implication of these activating mutations remains uncertain as moderately sized …
prognostic implication of these activating mutations remains uncertain as moderately sized …
Detection of a Recurrent DNAJB1-PRKACA Chimeric Transcript in Fibrolamellar Hepatocellular Carcinoma
Fibrolamellar hepatocellular carcinoma (FL-HCC) is a rare liver tumor affecting adolescents
and young adults with no history of primary liver disease or cirrhosis. We identified a …
and young adults with no history of primary liver disease or cirrhosis. We identified a …
[HTML][HTML] Mechanisms of parenchymal injury and signaling pathways in ectatic ducts of chronic pancreatitis: implications for pancreatic carcinogenesis
UK Bhanot, P Möller - Laboratory investigation, 2009 - Elsevier
The pathobiology of chronic pancreatitis (CP) remains enigmatic despite remarkable
progress made recently in uncovering key mechanisms involved in the initiation and …
progress made recently in uncovering key mechanisms involved in the initiation and …
ILC2s amplify PD-1 blockade by activating tissue-specific cancer immunity
Group 2 innate lymphoid cells (ILC2s) regulate inflammation and immunity in mammalian
tissues,. Although ILC2s are found in cancers of these tissues, their roles in cancer immunity …
tissues,. Although ILC2s are found in cancers of these tissues, their roles in cancer immunity …
NF-κB regulates androgen receptor expression and prostate cancer growth
L Zhang, S Altuwaijri, F Deng, L Chen, P Lal… - The American journal of …, 2009 - Elsevier
Prostate cancers that progress during androgen-deprivation therapy often overexpress the
androgen receptor (AR) and depend on AR signaling for growth. In most cases, increased …
androgen receptor (AR) and depend on AR signaling for growth. In most cases, increased …
[PDF][PDF] Concurrent mutations in STK11 and KEAP1 promote ferroptosis protection and SCD1 dependence in lung cancer
…, A Martin, E de Stanchina, U Bhanot… - Cell reports, 2020 - cell.com
Concurrent loss-of-function mutations in STK11 and KEAP1 in lung adenocarcinoma
(LUAD) are associated with aggressive tumor growth, resistance to available therapies, and …
(LUAD) are associated with aggressive tumor growth, resistance to available therapies, and …
Genomic biomarkers of a randomized trial comparing first-line everolimus and sunitinib in patients with metastatic renal cell carcinoma
…, N Weinhold, N Bouvier, KH Huberman, U Bhanot… - European urology, 2017 - Elsevier
Background Metastatic renal cell carcinoma (RCC) patients are commonly treated with
vascular endothelial growth factor (VEGF) inhibitors or mammalian target of rapamycin …
vascular endothelial growth factor (VEGF) inhibitors or mammalian target of rapamycin …
Whole-genome sequencing identifies a recurrent functional synonymous mutation in melanoma
JJ Gartner, SCJ Parker, TD Prickett… - Proceedings of the …, 2013 - National Acad Sciences
Synonymous mutations, which do not alter the protein sequence, have been shown to affect
protein function [Sauna ZE, Kimchi-Sarfaty C (2011) Nat Rev Genet 12 (10): 683–691] …
protein function [Sauna ZE, Kimchi-Sarfaty C (2011) Nat Rev Genet 12 (10): 683–691] …