Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer

…, JA Moral, R Remark, B Herbst, G Askan, U Bhanot… - Nature, 2017 - nature.com
Pancreatic ductal adenocarcinoma is a lethal cancer with fewer than 7% of patients
surviving past 5 years. T-cell immunity has been linked to the exceptional outcome of the few …

[PDF][PDF] Signatures of plasticity, metastasis, and immunosuppression in an atlas of human small cell lung cancer

JM Chan, A Quintanal-Villalonga, VR Gao, Y Xie… - Cancer cell, 2021 - cell.com
Small cell lung cancer (SCLC) is an aggressive malignancy that includes subtypes defined
by differential expression of ASCL1, NEUROD1, and POU2F3 (SCLC-A,-N, and-P …

PIK3CA mutation associates with improved outcome in breast cancer

K Kalinsky, LM Jacks, A Heguy, S Patil, M Drobnjak… - Clinical cancer …, 2009 - AACR
Purpose: In breast cancer, somatic mutations in the PIK3CA gene are common. The
prognostic implication of these activating mutations remains uncertain as moderately sized …

Detection of a Recurrent DNAJB1-PRKACA Chimeric Transcript in Fibrolamellar Hepatocellular Carcinoma

…, R Belote, S Germer, AK Emde, V Vacic, U Bhanot… - Science, 2014 - science.org
Fibrolamellar hepatocellular carcinoma (FL-HCC) is a rare liver tumor affecting adolescents
and young adults with no history of primary liver disease or cirrhosis. We identified a …

[HTML][HTML] Mechanisms of parenchymal injury and signaling pathways in ectatic ducts of chronic pancreatitis: implications for pancreatic carcinogenesis

UK Bhanot, P Möller - Laboratory investigation, 2009 - Elsevier
The pathobiology of chronic pancreatitis (CP) remains enigmatic despite remarkable
progress made recently in uncovering key mechanisms involved in the initiation and …

ILC2s amplify PD-1 blockade by activating tissue-specific cancer immunity

…, M Gururajan, D Redmond, G Askan, U Bhanot… - Nature, 2020 - nature.com
Group 2 innate lymphoid cells (ILC2s) regulate inflammation and immunity in mammalian
tissues,. Although ILC2s are found in cancers of these tissues, their roles in cancer immunity …

NF-κB regulates androgen receptor expression and prostate cancer growth

L Zhang, S Altuwaijri, F Deng, L Chen, P Lal… - The American journal of …, 2009 - Elsevier
Prostate cancers that progress during androgen-deprivation therapy often overexpress the
androgen receptor (AR) and depend on AR signaling for growth. In most cases, increased …

[PDF][PDF] Concurrent mutations in STK11 and KEAP1 promote ferroptosis protection and SCD1 dependence in lung cancer

…, A Martin, E de Stanchina, U Bhanot… - Cell reports, 2020 - cell.com
Concurrent loss-of-function mutations in STK11 and KEAP1 in lung adenocarcinoma
(LUAD) are associated with aggressive tumor growth, resistance to available therapies, and …

Genomic biomarkers of a randomized trial comparing first-line everolimus and sunitinib in patients with metastatic renal cell carcinoma

…, N Weinhold, N Bouvier, KH Huberman, U Bhanot… - European urology, 2017 - Elsevier
Background Metastatic renal cell carcinoma (RCC) patients are commonly treated with
vascular endothelial growth factor (VEGF) inhibitors or mammalian target of rapamycin …

Whole-genome sequencing identifies a recurrent functional synonymous mutation in melanoma

JJ Gartner, SCJ Parker, TD Prickett… - Proceedings of the …, 2013 - National Acad Sciences
Synonymous mutations, which do not alter the protein sequence, have been shown to affect
protein function [Sauna ZE, Kimchi-Sarfaty C (2011) Nat Rev Genet 12 (10): 683–691] …