Mucosal antibodies in inflammatory bowel disease are directed against intestinal bacteria.
A Macpherson, UY Khoo, I Forgacs, J Philpott-Howard… - Gut, 1996 - gut.bmj.com
In contrast with normal subjects where IgA is the main immunoglobulin in the intestine,
patients with active inflammatory bowel disease (IBD) produce high concentrations of IgG …
patients with active inflammatory bowel disease (IBD) produce high concentrations of IgG …
CD4+ T cell down-regulation in human intestinal mucosa: evidence for intestinal tolerance to luminal bacterial antigens.
UY Khoo, IE Proctor, AJ Macpherson - Journal of immunology …, 1997 - journals.aai.org
T cells from the intestinal mucosal proliferate poorly in vitro, and the contribution of Ag-
specific recognition to this hyporesponsiveness is unclear, since the Ag repertoire of …
specific recognition to this hyporesponsiveness is unclear, since the Ag repertoire of …
Immunological heterogeneity in type I diabetes: presence of distinct autoantibody patterns in patients with acute onset and slowly progressive disease
J Seissler, JJJ De Sonnaville, NG Morgenthaler… - Diabetologia, 1998 - Springer
Type I diabetes mellitus may represent a heterogeneous disorder with a distinct
pathogenesis in patients with young and adult onset of the disease. To investigate whether …
pathogenesis in patients with young and adult onset of the disease. To investigate whether …
Antibodies to colonic epithelial cells from the serum and colonic mucosal washings in ulcerative colitis.
UY Khoo, I Bjarnason, A Donaghy, R Williams… - Gut, 1995 - gut.bmj.com
It has been suggested that antibodies to a colonocyte protein of 40 kD (an intestinal isoform
of tropomyosin) are specifically found in the serum and mucosa of patients with ulcerative …
of tropomyosin) are specifically found in the serum and mucosa of patients with ulcerative …
The influence of glycation on the peroxidase activity of haemoglobin
UY Khoo, DJ Newman, WK Miller, CP Price - 1994 - degruyter.com
The peroxidase activity of haemoglobin A was characterized for non-glycated and glycated
haemoglobin!(HbAj) within the pH ränge 4.5 to 6.0, by measuring the rate of oxidation of 5 …
haemoglobin!(HbAj) within the pH ränge 4.5 to 6.0, by measuring the rate of oxidation of 5 …
Detection of autoantibodies to the diabetes-associated antigen IA-2 by a sensitive enzyme-linked immunosorbent assay
K Löbner, UY Khoo-Morgenthaler… - Hormone and …, 1999 - thieme-connect.com
The tyrosine phosphatase like protein IA-2 is an important autoantigen in insulin-dependent
diabetes mellitus (type 1 diabetes). Autoantibodies to IA-2 (IA-2A) are present in the serum …
diabetes mellitus (type 1 diabetes). Autoantibodies to IA-2 (IA-2A) are present in the serum …
T cell reactivity to DR* 0401-and DQ* 0302-binding peptides of the putative autoantigen IA-2 in type 1 diabetes
T Lohmann, T Halder, J Engler… - Experimental and …, 1999 - thieme-connect.com
Type 1 diabetes is thought to be an autoimmune disease mediated by T lymphocytes
recognizing critical islet cell antigens. Recently, the tyrosine phosphatase like protein IA-2 …
recognizing critical islet cell antigens. Recently, the tyrosine phosphatase like protein IA-2 …
Mitochondrial gene expression in small intestinal epithelial cells
TP Mayall, I Bjarnason, UY Khoo, TJ Peters… - Biochemical …, 1995 - portlandpress.com
Most mitochondrial genes are transcribed as a single large transcript from the heavy strand
of mitochondrial DNA, and are subsequently processed into the proximal mitochondrial (mt) …
of mitochondrial DNA, and are subsequently processed into the proximal mitochondrial (mt) …
Inflammatory bowel disease of mice--and men?
AJS Macpherson, UY Khoo - The Lancet, 1994 - elibrary.ru
Discusses the causes of inflammatory bowel disease. Persistent infection with an
unidentified pathogen; Inappropriate response by the mucosal immune system to …
unidentified pathogen; Inappropriate response by the mucosal immune system to …
CD4+ T cell downregulation in the intestinal mucosa: Evidence for intestinal tolerance to luminal bacterial antigens
A Macpherson, UY Khoo, E Hardinge, C McGregor… - Immunology …, 1997 - infona.pl
Introduction: The mucosal immune system is required to respond to intestinal pathogens, yet
tolerate the luxuriant commensal flora of the lower small intestine and the colon. In addition …
tolerate the luxuriant commensal flora of the lower small intestine and the colon. In addition …