Induction of Gastric Epithelial Cell Apoptosis by Helicobacter pylori Vacuolating Cytotoxin

TL Cover, US Krishna, DA Israel, RM Peek Jr - Cancer research, 2003 - AACR
Chronic gastritis induced by Helicobacter pylori is a strong risk factor for thedevelopment of
distal gastric adenocarcinoma. A specific host response to H. pylori that may contribute to …

Helicobacter pylori Flagellin Evades Toll-Like Receptor 5-Mediated Innate Immunity

AT Gewirtz, Y Yu, US Krishna, DA Israel… - Journal of Infectious …, 2004 - academic.oup.com
Helicobacter pylori colonizes the human stomach for decades unless pharmacologically
eradicated. We hypothesized that this flagellated pathogen escapes immune clearance, in …

Pathogenic H elicobacter pylori strains translocate DNA and activate TLR9 via the cancer-associated cag type IV secretion system

MG Varga, CL Shaffer, JC Sierra, G Suarez… - Oncogene, 2016 - nature.com
Helicobacter pylori (H. pylori) is the strongest identified risk factor for gastric cancer, the third
most common cause of cancer-related death worldwide. An H. pylori constituent that …

Helicobacter pylori strain-selective induction of matrix metalloproteinase-7 in vitro and within gastric mucosa

HC Crawford, US Krishna, DA Israel, LM Matrisian… - Gastroenterology, 2003 - Elsevier
Background & Aims: Helicobacter pylori strains that possess the cag pathogenicity island
(cag+) augment the risk for distal gastric cancer. Matrix metalloproteinase (MMP)-7, an …

p120 and Kaiso Regulate Helicobacter pylori-induced Expression of Matrix Metalloproteinase-7

SR Ogden, LE Wroblewski, C Weydig… - Molecular biology of …, 2008 - Am Soc Cell Biol
Helicobacter pylori is the strongest known risk factor for gastric adenocarcinoma, yet only a
fraction of infected persons develop cancer. One H. pylori constituent that augments disease …

Helicobacter pylori-induced cell death is counteracted by NF-κB-mediated transcription of DARPP-32

S Zhu, M Soutto, Z Chen, DF Peng, J Romero-Gallo… - Gut, 2017 - gut.bmj.com
Objective DARPP-32 is a frequently amplified and overexpressed gene that promotes
several oncogenic functions in gastric cancer. Herein, we investigated the relationship …

[HTML][HTML] Helicobacter Pylori Promotes the Expression of Krüppel-Like Factor 5, a Mediator of Carcinogenesis, In Vitro and In Vivo

JM Noto, T Khizanishvili, R Chaturvedi, MB Piazuelo… - PloS one, 2013 - journals.plos.org
Helicobacter pylori is the strongest known risk factor for the development of gastric
adenocarcinoma. H. pylori expresses a repertoire of virulence factors that increase gastric …

TLR9 activation suppresses inflammation in response to Helicobacter pylori infection

MG Varga, MB Piazuelo… - American Journal …, 2016 - journals.physiology.org
Helicobacter pylori (H. pylori) induces chronic gastritis in humans, and infection can persist
for decades. One H. pylori strain-specific constituent that augments disease risk is the cag …

Trefoil factor 1 expression suppresses Helicobacter pylori–induced inflammation in gastric carcinogenesis

M Soutto, Z Chen, AM Katsha, J Romero‐Gallo… - Cancer, 2015 - Wiley Online Library
BACKGROUND Infection with Helicobacter pylori, a high‐risk factor for gastric cancer, is
frequently associated with chronic inflammation through activation of nuclear factor κB (NF …

Genetic Manipulation of Helicobacter pylori Virulence Function by Host Carcinogenic Phenotypes

G Suarez, J Romero-Gallo, JC Sierra, MB Piazuelo… - Cancer research, 2017 - AACR
Helicobacter pylori is the strongest risk factor for gastric adenocarcinoma, yet only a minority
of infected persons ever develop this malignancy. One cancer-linked locus is the cag type 4 …