A great effort of research has been devoted in the last few years to developing new anti-HBV
therapies of finite duration that also provide effective sustained control of virus replication …

Chronic hepatitis B virus (HBV) infection represents a worldwide public health concern with
approximately 250 million people chronically infected and at risk of developing liver cirrhosis …

Hepatitis B virus (HBV)-specific CD8 T cells are functionally exhausted in chronic hepatitis B
infection, and this condition can be corrected only partially through the modulation of …

Immune modulatory therapies are widely believed to represent potential therapeutic
strategies for chronic hepatitis B infection (CHB). Among the cellular targets for immune …

Background & Aims One strategy to treat chronic hepatitis B virus (HBV) infection could be to
increase the functions of virus-specific T cells. We performed a multicenter phase 2 study to …

Natural killer (NK) and hepatitis B virus (HBV)‐specific T cells are functionally impaired in
chronic hepatitis B (CHB). Understanding to what extent nucleos (t) ide analogue (NUC) …

By serving as the sole output of the cerebellar cortex, integrating a myriad of afferent stimuli,
Purkinje cells (PCs) constitute the principal neuron in cerebellar circuits. Several …

Background & Aims In chronic HBV infection, mitochondrial functions and proteostasis are
dysregulated in exhausted HBV-specific CD8 T cells. To better characterise the potential …

Abstract Background PTEN Hamartoma Tumor Syndrome (PHTS) is a rare syndrome with a
broad phenotypic spectrum, including increased risks of breast (BC, 67%-78% at age 60 …

Hepatitis C virus infection (HCV) represents a unique model to characterize, from early to
late stages of infection, the T cell differentiation process leading to exhaustion of human …