A disrupted RNA editing balance mediated by ADARs (Adenosine DeAminases that act on RNA) in human hepatocellular carcinoma
Objective Hepatocellular carcinoma (HCC) is a heterogeneous tumour displaying a complex
variety of genetic and epigenetic changes. In human cancers, aberrant post-transcriptional …
variety of genetic and epigenetic changes. In human cancers, aberrant post-transcriptional …
ADAR-mediated RNA editing predicts progression and prognosis of gastric cancer
Backgroud & Aims Gastric cancer (GC) is the third leading cause of global cancer mortality.
Adenosine-to-inosine RNA editing is a recently described novel epigenetic mechanism …
Adenosine-to-inosine RNA editing is a recently described novel epigenetic mechanism …
[HTML][HTML] ADARs act as potent regulators of circular transcriptome in cancer
Circular RNAs (circRNAs) are produced by head-to-tail back-splicing which is mainly
facilitated by base-pairing of reverse complementary matches (RCMs) in circRNA flanking …
facilitated by base-pairing of reverse complementary matches (RCMs) in circRNA flanking …
[HTML][HTML] Cis- and trans-regulations of pre-mRNA splicing by RNA editing enzymes influence cancer development
RNA editing and splicing are the two major processes that dynamically regulate human
transcriptome diversity. Despite growing evidence of crosstalk between RNA editing …
transcriptome diversity. Despite growing evidence of crosstalk between RNA editing …
Suppression of adenosine-to-inosine (A-to-I) RNA editome by death associated protein 3 (DAP3) promotes cancer progression
RNA editing introduces nucleotide changes in RNA sequences. Recent studies have
reported that aberrant A-to-I RNA editing profiles are implicated in cancers. Albeit changes …
reported that aberrant A-to-I RNA editing profiles are implicated in cancers. Albeit changes …
An RNA editing/dsRNA binding-independent gene regulatory mechanism of ADARs and its clinical implication in cancer
Abstract Adenosine-to-inosine (A-to-I) RNA editing, catalyzed by Adenosine DeAminases
acting on double-stranded RNA (dsRNA)(ADAR), occurs predominantly in the 3 …
acting on double-stranded RNA (dsRNA)(ADAR), occurs predominantly in the 3 …
[HTML][HTML] RNA editing mediates the functional switch of COPA in a novel mechanism of hepatocarcinogenesis
Background & Aims RNA editing introduces nucleotide changes in RNA sequences. Recent
studies have reported that aberrant adenosine-to-inosine RNA editing is implicated in …
studies have reported that aberrant adenosine-to-inosine RNA editing is implicated in …
[HTML][HTML] Multilayered control of splicing regulatory networks by DAP3 leads to widespread alternative splicing changes in cancer
The dynamic regulation of alternative splicing requires coordinated participation of multiple
RNA binding proteins (RBPs). Aberrant splicing caused by dysregulation of splicing …
RNA binding proteins (RBPs). Aberrant splicing caused by dysregulation of splicing …
Antisense RNAs influence promoter usage of their counterpart sense genes in cancer
F Bellido Molias, A Sim, KW Leong, O An, Y Song… - Cancer Research, 2021 - AACR
Multiple noncoding natural antisense transcripts (ncNAT) are known to modulate key
biological events such as cell growth or differentiation. However, the actual impact of …
biological events such as cell growth or differentiation. However, the actual impact of …
Core-binding factor fusion downregulation of ADAR2 RNA editing contributes to AML leukemogenesis
Adenosine-to-inosine RNA editing, which is catalyzed by adenosine deaminases acting on
RNA (ADAR) family of enzymes, ADAR1 and ADAR2, has been shown to contribute to …
RNA (ADAR) family of enzymes, ADAR1 and ADAR2, has been shown to contribute to …