Risk factors for symptomatic venous and arterial thromboembolism in newborns, children and adolescents–what did we learn within the last 20 years?

G Kenet, V Limperger, M Shneyder… - Blood Cells, Molecules …, 2017 - Elsevier
Venous thrombosis (VTE) in children is increasingly diagnosed, as advanced medical care
has increased treatment intensity of hospitalized pediatric patients. The aim of this review …

End-stage renal disease and thrombophilia

A Bauer, V Limperger, U Nowak-Göttl - Hämostaseologie, 2016 - thieme-connect.com
Chronic kidney disease is an established risk factor for arterial and venous
thromboembolism (TE). Whereas the overall risk of TE in moderately decreased kidney …

Developmental hemostasis: a lifespan from neonates and pregnancy to the young and elderly adult in a European white population

U Nowak-Göttl, V Limperger, G Kenet… - Blood Cells, Molecules …, 2017 - Elsevier
Absolute values of reference ranges for coagulation assays in humans vary within the entire
lifespan and confirm the concept of developmental hemostasis. It is known that physiologic …

Genome-wide analysis of 944 133 individuals provides insights into the etiology of haemorrhoidal disease

T Zheng, D Ellinghaus, S Juzenas, F Cossais… - Gut, 2021 - gut.bmj.com
Objective Haemorrhoidal disease (HEM) affects a large and silently suffering fraction of the
population but its aetiology, including suspected genetic predisposition, is poorly …

Bleeding issues in neonates and infants–update 2015

U Nowak-Göttl, V Limperger, A Bauer, D Kowalski… - Thrombosis …, 2015 - Elsevier
The presentation of a neonate with clinical bleeding symptoms commonly causes
considerable anxiety to parents and treating physicians. Since inherited coagulation …

Role of protein S deficiency in children with venous thromboembolism

UC Klostermeier, V Limperger, G Kenet… - Thrombosis and …, 2015 - thieme-connect.com
Venous thromboembolism [TE] is a multifactorial disease, and protein S deficiency [PSD]
constitutes a major risk factor. In the present study the prevalence of PSD and the clinical …

Clinical and laboratory characteristics of paediatric and adolescent index cases with venous thromboembolism and antithrombin deficiency

V Limperger, A Franke, G Kenet… - Thrombosis and …, 2014 - thieme-connect.com
Venous thromboembolism [TE] is a multifactorial disease and antithrombin deficiency [ATD]
constitutes a major risk factor. In the present study the prevalence of ATD and the clinical …

Clinical and laboratory characteristics of children with venous thromboembolism and protein C‐deficiency: an observational Israeli‐German cohort study

V Limperger, UC Klostermeier, G Kenet… - British journal of …, 2014 - Wiley Online Library
Venous thromboembolism [TE] is a multifactorial disease and protein C deficiency [PCD]
constitutes a major risk factor. In the present study the prevalence of PCD and the clinical …

Impact of high‐risk thrombophilia status on recurrence among children with a first non‐central‐venous‐catheter‐associated VTE: an observational multicentre cohort …

V Limperger, G Kenet, NA Goldenberg… - British journal of …, 2016 - Wiley Online Library
Deficiency of antithrombin (AT), protein C (PC) or protein S (PS) constitutes a major risk
factor for venous thromboembolism (VTE). Individuals at high risk for recurrence who benefit …

Rare genetic variants in SMAP1, B3GAT2, and RIMS1 contribute to pediatric venous thromboembolism

F Rühle, A Witten, A Barysenka, A Huge… - Blood, The Journal …, 2017 - ashpublications.org
Recent genome-wide association studies (GWAS) have confirmed known risk mutations for
venous thromboembolism (VTE) and identified a number of novel susceptibility loci in adults …