Pancreatic ductal adenocarcinoma (PDAC) belongs to the most lethal solid tumors in
humans. A histological hallmark feature of PDAC is the pronounced tumor microenvironment …

Background: Severe acute pancreatitis (AP) continues to be a serious gastrointestinal
disease with relevant morbidity and mortality. Summary: Successful clinical management …

Owing to its aggressiveness, late detection and marginal therapeutic accessibility,
pancreatic ductal adenocarcinoma (PDAC) remains a most challenging malignant disease …

The aim of this study was to examine the effects of transforming growth factor (TGF) β1 on
the phenotype and the biological behavior of pancreatic cancer cell lines with and without …

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal human cancers and
shows resistance to any therapeutic strategy used. Here we tested small-molecule inhibitors …

The nuclear factor of activated T cell (NFAT) proteins are a family of Ca2+/calcineurin‐
responsive transcription factors primarily recognized for their central roles in T lymphocyte …

Activation of matrix metalloproteinase‐2 (MMP‐2) by the membrane‐type matrix
metalloproteinases (MT‐MMPs) has been associated with tumor progression. In the present …

Macroautophagy is an evolutionarily conserved cellular process involved in the clearance of
proteins and organelles. Although the cytoplasmic machinery that orchestrates autophagy …

Sp1-like proteins are defined by three highly homologous C2H2 zinc finger motifs that bind
GC-rich sequences found in the promoters of a large number of genes essential for …

Design Pharmacokinetic and pharmacodynamic parameters of cremophor-paclitaxel, nab-
paclitaxel (human-albumin-bound paclitaxel, Abraxane) and a novel mouse-albumin-bound …