As a point of convergence for numerous oncogenic signaling pathways, signal transducer
and activator of transcription 3 (STAT3) is central in regulating the anti-tumor immune …

Overnutrition is a risk factor for various human diseases, including neurodegenerative
diseases, metabolic disorders, and cancers. Therefore, targeting overnutrition represents a …

Liver cancer, particularly hepatocellular carcinoma (HCC), is the third leading cause of
cancer death in the world. Bile acids (BAs) are liver-produced amphipathic molecules that …

Ferroptosis is a nonapoptotic cell death process that requires cellular iron and the
accumulation of lipid peroxides. In progressive rheumatoid arthritis (RA), synovial fibroblasts …

MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression by
interacting with the 3′ untranslated region (3′‐UTR) of multiple mRNAs. Recent studies …

Type 2 diabetes (T2D) is characterized by insulin resistance and increased hepatic glucose
production, yet the molecular mechanisms underlying these abnormalities are poorly …

Understanding of dedifferentiation, an indicator of poo prognosis for patients with thyroid
cancer, has been hampered by imprecise and incomplete characterization of its …

SARS-CoV-2 mutations contribute to increased viral transmissibility and immune escape,
compromising the effectiveness of existing vaccines and neutralizing antibodies. An in-depth …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection continues to have
devastating consequences worldwide. Recently, great efforts have been made to identify …

Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disease characterized by
excessive proliferation of fibroblasts and excessive accumulation of extracellular matrix …