Macrophages in intestinal inflammation and resolution: a potential therapeutic target in IBD
Macrophages are the gatekeepers of intestinal immune homeostasis as they discriminate
between innocuous antigens and potential pathogens to maintain oral tolerance. However …
between innocuous antigens and potential pathogens to maintain oral tolerance. However …
Metabolic features of macrophages in inflammatory diseases and cancer
Macrophages are now considered to be important players in various inflammatory diseases
as well as tumor progression. Emerging evidence reveals that macrophage metabolic …
as well as tumor progression. Emerging evidence reveals that macrophage metabolic …
[HTML][HTML] A new era of macrophage-based cell therapy
Macrophages are essential innate immune cells found throughout the body that have
protective and pathogenic functions in many diseases. When activated, macrophages can …
protective and pathogenic functions in many diseases. When activated, macrophages can …
[HTML][HTML] Cyclooxygenase-2 inhibition blocks M2 macrophage differentiation and suppresses metastasis in murine breast cancer model
Tumor cells are often associated with abundant macrophages that resemble the alternatively
activated M2 subset. Tumor-associated macrophages (TAMs) inhibit anti-tumor immune …
activated M2 subset. Tumor-associated macrophages (TAMs) inhibit anti-tumor immune …
[HTML][HTML] GM-CSF grown bone marrow derived cells are composed of phenotypically different dendritic cells and macrophages
Granulocyte-macrophage colony stimulating factor (GM-CSF) has a role in inducing
emergency hematopoiesis upon exposure to inflammatory stimuli. Although GM-CSF …
emergency hematopoiesis upon exposure to inflammatory stimuli. Although GM-CSF …
[HTML][HTML] Production of specific antibodies against SARS-coronavirus nucleocapsid protein without cross reactivity with human coronaviruses 229E and OC43
Severe acute respiratory syndrome (SARS) is a life-threatening disease for which accurate
diagnosis is essential. Although many tools have been developed for the diagnosis of …
diagnosis is essential. Although many tools have been developed for the diagnosis of …
GM-CSF induces inflammatory macrophages by regulating glycolysis and lipid metabolism
GM-CSF induces proinflammatory macrophages, but the underlying mechanisms have not
been studied thus far. In this study, we investigated the mechanisms of how GM-CSF …
been studied thus far. In this study, we investigated the mechanisms of how GM-CSF …
Prostaglandin E2 receptor PTGER4-expressing macrophages promote intestinal epithelial barrier regeneration upon inflammation
YR Na, D Jung, M Stakenborg, H Jang, GJ Gu… - Gut, 2021 - gut.bmj.com
Objective Dysfunctional resolution of intestinal inflammation and altered mucosal healing
are essential features in the pathogenesis of inflammatory bowel disease (IBD). Intestinal …
are essential features in the pathogenesis of inflammatory bowel disease (IBD). Intestinal …
Bone morphogenetic protein 7 induces mesenchymal‐to‐epithelial transition in melanoma cells, leading to inhibition of metastasis
Bone morphogenetic protein (BMP) 7 counteracts physiological epithelial‐to‐mesenchymal
transition, a process that is indicative of epithelial plasticity in developmental stages …
transition, a process that is indicative of epithelial plasticity in developmental stages …
Pyruvate dehydrogenase kinase is a negative regulator of interleukin-10 production in macrophages
YR Na, D Jung, J Song, JW Park… - Journal of molecular …, 2020 - academic.oup.com
Abstract Interleukin-10 (IL-10) is the most potent anti-inflammatory cytokine in the body and
plays an essential role in determining outcomes of many inflammatory diseases. Cellular …
plays an essential role in determining outcomes of many inflammatory diseases. Cellular …