Lung squamous cell carcinoma (LSCC) pathogenesis remains incompletely understood,
and biomarkers predicting treatment response remain lacking. Here, we describe novel …

Abstract Purpose: Activation of NFE2L2 has been linked to chemoresistance in cell line
models. Recently, somatic mutations that activate NFE2L2, including mutations in NFE2L2 …

Extracellular vesicles (EVs) mediate cell-cell crosstalk by carrying bioactive molecules
derived from cells. Recently, immune cell-derived EVs have been reported to regulate key …

During development, the formation of a mature, well-functioning heart requires
transformation of the ventricular wall from a loose trabecular network into a dense compact …

The MAPK pathway mediates TLR signaling during innate immune responses. We
discovered previously that MKP-1 is acetylated, enhancing its interaction with its MAPK …

The anticancer actions of vitamin D and its hormonally active form, calcitriol, have been
extensively documented in clinical and preclinical studies. However, the mechanisms …

Background Tumors comprise a complex microenvironment of interacting malignant and
stromal cell types. Much of our understanding of the tumor microenvironment comes from in …

Erythropoietin (EPO) is a hormone that induces red blood cell production. In its recombinant
form, EPO is the one of most prescribed drugs to treat anemia, including that arising in …

Although elevated levels of aldosterone are associated with vascular inflammation, the
proinflammatory pathways of aldosterone are not completely defined. We now show that …

Non-small cell lung carcinoma (NSCLC) is leading cause of cancer-related deaths in the
world. The Tumor Suppressor Candidate 3 (TUSC3) at chromosome 8p22 known to be …