A novel myokine, secreted protein acidic and rich in cysteine (SPARC), suppresses colon tumorigenesis via regular exercise

W Aoi, Y Naito, T Takagi, Y Tanimura, Y Takanami… - Gut, 2013 - gut.bmj.com
Objective Several epidemiological studies have shown that regular exercise can prevent the
onset of colon cancer, although the underlying mechanism is unclear. Myokines are …

[HTML][HTML] Muscle-enriched microRNA miR-486 decreases in circulation in response to exercise in young men

W Aoi, H Ichikawa, K Mune, Y Tanimura… - Frontiers in …, 2013 - frontiersin.org
Background: MicroRNAs (miRNAs) are small non-coding RNAs involved in post-
transcriptional gene regulation. miRNAs are taken in by intracellular exosomes, secreted …

[HTML][HTML] Roles of skeletal muscle-derived exosomes in organ metabolic and immunological communication

W Aoi, Y Tanimura - Frontiers in Endocrinology, 2021 - frontiersin.org
Skeletal muscles secrete various factors, such as proteins/peptides, nucleotides, and
metabolites, which are referred to as myokines. Many of these factors are transported into …

Vascular endothelium-derived factors and arterial stiffness in strength-and endurance-trained men

T Otsuki, S Maeda, M Iemitsu, Y Saito… - American Journal …, 2007 - journals.physiology.org
Arterial stiffness is higher in strength-trained humans and lower in endurance-trained
humans. However, the mechanisms underlying these different adaptations are unclear …

Acute exercise increases fibroblast growth factor 21 in metabolic organs and circulation

Y Tanimura, W Aoi, Y Takanami, Y Kawai… - Physiological …, 2016 - Wiley Online Library
Fibroblast growth factor 21, a metabolic regulator, plays roles in lipolysis and glucose uptake
in adipose tissues and skeletal muscles. Its expression in skeletal muscle is upregulated …

Reducing exercise-induced muscular injury in kendo athletes with supplementation of coenzyme Q10

M Kon, K Tanabe, T Akimoto, F Kimura… - British journal of …, 2008 - cambridge.org
Intensive physical exercise may cause muscular injury and increase oxidative stress. The
purpose of this study was to examine the effect of an antioxidant, coenzyme Q10 (CoQ10) …

Relationship between arterial stiffness and athletic training programs in young adult men

T Otsuki, S Maeda, M Iemitsu, Y Saito… - American journal of …, 2007 - academic.oup.com
Background: We examined the relationships of endurance and strength exercise training
and the adolescent duration of training to arterial stiffness in young adult men. We …

Postexercise heart rate recovery accelerates in strength-trained athletes.

T Otsuki, S Maeda, M Iemitsu, Y Saito… - Medicine and science …, 2007 - europepmc.org
Purpose The purpose of this study was to investigate whether postexercise HR recovery
accelerates in strength-trained athletes. Methods Subjects were young strength-trained …

Maternal age affects pronuclear and chromatin dynamics, morula compaction and cell polarity, and blastulation of human embryos

K Ezoe, T Miki, H Akaike, K Shimazaki… - Human …, 2023 - academic.oup.com
STUDY QUESTION Does maternal ageing impact early and late morphokinetic and cellular
processes of human blastocyst formation? SUMMARY ANSWER Maternal ageing …

Regular exercise reduces colon tumorigenesis associated with suppression of iNOS

W Aoi, Y Naito, T Takagi, S Kokura, K Mizushima… - Biochemical and …, 2010 - Elsevier
Several epidemiological studies have shown that regular exercise can prevent the onset of
colon cancer, although the mechanism involved is unclear. Expression of inducible nitric …