User profiles for "author:Yury V Popov"
 | Yury V. PopovAssociate Professor of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical … Verified email at bidmc.harvard.edu Cited by 7226 |
Lysyl oxidase (LOX) family members: rationale and their potential as therapeutic targets for liver fibrosis
The cross‐linking of structural extracellular matrix (ECM) components, especially fibrillar
collagens and elastin, is strongly implicated in fibrosis progression and resistance to fibrosis …
collagens and elastin, is strongly implicated in fibrosis progression and resistance to fibrosis …
[HTML][HTML] COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets
COVID-19, which is caused by SARS-CoV-2, can result in acute respiratory distress
syndrome and multiple organ failure,,–, but little is known about its pathophysiology. Here …
syndrome and multiple organ failure,,–, but little is known about its pathophysiology. Here …
[HTML][HTML] Hepatocyte mitochondria-derived danger signals directly activate hepatic stellate cells and drive progression of liver fibrosis
P An, LL Wei, S Zhao, DY Sverdlov, KA Vaid… - Nature …, 2020 - nature.com
Due to their bacterial ancestry, many components of mitochondria share structural
similarities with bacteria. Release of molecular danger signals from injured cell mitochondria …
similarities with bacteria. Release of molecular danger signals from injured cell mitochondria …
Selective targeting of lysyl oxidase-like 2 (LOXL2) suppresses hepatic fibrosis progression and accelerates its reversal
Background/Aims We studied the role of lysyl oxidase-like 2 (LOXL2) in collagen
crosslinking and hepatic progenitor cell (HPC) differentiation, and the therapeutic efficacy of …
crosslinking and hepatic progenitor cell (HPC) differentiation, and the therapeutic efficacy of …
[PDF][PDF] Telomere dysfunction induces sirtuin repression that drives telomere-dependent disease
H Amano, A Chaudhury, C Rodriguez-Aguayo, L Lu… - Cell metabolism, 2019 - cell.com
Telomere shortening is associated with stem cell decline, fibrotic disorders, and premature
aging through mechanisms that are incompletely understood. Here, we show that telomere …
aging through mechanisms that are incompletely understood. Here, we show that telomere …
Protective and aggressive bacterial subsets and metabolites modify hepatobiliary inflammation and fibrosis in a murine model of PSC
Objective Conflicting microbiota data exist for primary sclerosing cholangitis (PSC) and
experimental models. Goal: define the function of complex resident microbes and their …
experimental models. Goal: define the function of complex resident microbes and their …
A novel non‐bile acid FXR agonist EDP‐305 potently suppresses liver injury and fibrosis without worsening of ductular reaction
Background EDP‐305 is a novel and potent farnesoid X receptor (FXR) agonist, with
no/minimal cross‐reactivity to TGR5 or other nuclear receptors. Herein we report therapeutic …
no/minimal cross‐reactivity to TGR5 or other nuclear receptors. Herein we report therapeutic …
Comparison of murine steatohepatitis models identifies a dietary intervention with robust fibrosis, ductular reaction, and rapid progression to cirrhosis and cancer
G Wei, P An, KA Vaid, I Nasser… - American Journal …, 2020 - journals.physiology.org
Progressive fibrosis, functional liver failure, and cancer are the central liver-related
outcomes of nonalcoholic steatohepatitis (NASH) but notoriously difficult to achieve in …
outcomes of nonalcoholic steatohepatitis (NASH) but notoriously difficult to achieve in …
[HTML][HTML] Synthetic human ABCB4 mRNA therapy rescues severe liver disease phenotype in a BALB/c. Abcb4-/-mouse model of PFIC3
Background & Aims Progressive familial intrahepatic cholestasis type 3 (PFIC3) is a rare
lethal autosomal recessive liver disorder caused by loss-of-function variations of the ABCB4 …
lethal autosomal recessive liver disorder caused by loss-of-function variations of the ABCB4 …
[HTML][HTML] A single-cell and spatial atlas of autopsy tissues reveals pathology and cellular targets of SARS-CoV-2
The SARS-CoV-2 pandemic has caused over 1 million deaths globally, mostly due to acute
lung injury and acute respiratory distress syndrome, or direct complications resulting in …
lung injury and acute respiratory distress syndrome, or direct complications resulting in …