Endothelin-1: physiological and pathological roles in myometrium

Z Tanfin, P Robin, C Oyeniran… - The international journal …, 2011 - Elsevier
Endothelin-1 (ET-1), a member of endothelin peptide family is released by many different
tissues including uterine smooth muscle. ET-1 acts through ETA and ETB receptors and is …

TGR5-dependent hepatoprotection through the regulation of biliary epithelium barrier function

G Merlen, N Kahale, J Ursic-Bedoya… - Gut, 2020 - gut.bmj.com
Objective We explored the hypothesis that TGR5, the bile acid (BA) G-protein-coupled
receptor highly expressed in biliary epithelial cells, protects the liver against BA overload …

ATP-binding cassette ABCC1 is involved in the release of sphingosine 1-phosphate from rat uterine leiomyoma ELT3 cells and late pregnant rat myometrium

Z Tanfin, M Serrano-Sanchez, D Leiber - Cellular signalling, 2011 - Elsevier
Sphingosine 1-phosphate (S1P), a bioactive lipid generated by sphingosine kinases
(SphK1/2), initiates different signalling pathways involved in physiological and pathological …

Study of orexins signal transduction pathways in rat olfactory mucosa and in olfactory sensory neurons-derived cell line Odora: multiple orexin signalling pathways

T Gorojankina, D Grébert, R Salesse, Z Tanfin… - Regulatory peptides, 2007 - Elsevier
Orexins A and B (OxA and OxB) are multifunctional neuropeptides implicated in the
regulation of energy metabolism, wakefulness but also in a broad range of motivated …

Exogenous sphingosine 1-phosphate and sphingosine kinase activated by endothelin-1 induced myometrial contraction through differential mechanisms

D Leiber, Y Banno, Z Tanfin - American Journal of …, 2007 - journals.physiology.org
Sphingosine 1-phosphate (S1P), a bioactive sphingolipid involved in diverse biological
processes, is generated by sphingosine kinase (SphK) and acts via intracellular and/or …

Signaling pathways involved in sphingosine kinase activation and sphingosine-1-phosphate release in rat myometrium in late pregnancy: role in the induction of …

M Serrano-Sanchez, Z Tanfin, D Leiber - Endocrinology, 2008 - academic.oup.com
We investigated the regulation of the sphingosine kinase (SphK)/sphingosine-1-phosphate
(S1P) axis and its role during pregnancy in the rat myometrium. SphK1 and SphK2 were …

Endothelin-1 inhibits apoptosis through a sphingosine kinase 1-dependent mechanism in uterine leiomyoma ELT3 cells

MN Raymond, C Bole-Feysot, Y Banno, Z Tanfin… - …, 2006 - academic.oup.com
Uterine leiomyomas, or fibroids, are the most common tumors of the myometrium. The ELT3
cell line, derived from Eker rat leiomyoma, has been successfully used as a model for the …

Surfactant protein A signaling pathways in human uterine smooth muscle cells

I Garcia-Verdugo, Z Tanfin, E Dallot… - Biology of …, 2008 - academic.oup.com
The present study investigated the ability of surfactant associated protein A1 (SFTPA1), a
major component of lung surfactant, to bind and serve as a signal in human cultured …

Contribution of PKC-dependent and-independent processes in temporal ERK regulation by ET-1, PDGF, and EGF in rat myometrial cells

P Robin, I Boulven, C Bôle-Feysot… - American Journal of …, 2004 - journals.physiology.org
Endothelin-1 (ET-1), platelet-derived growth factor (PDGF), and epidermal growth factor
(EGF) stimulated thymidine incorporation with different efficiency (PDGF≫ EGF= ET-1) in rat …

The endothelin axis in uterine leiomyomas: new insights

Z Tanfin, M Breuiller-Fouché - Biology of reproduction, 2012 - academic.oup.com
The endothelin axis, comprising endothelin-1 (ET-1) and its receptors (ETA and ETB), is
involved in the pathophysiology of different human tumors. Here we review conventional …