Research Article
Intragastric bacterial activity and nitrosation before, during, and after treatment with omeprazole.
Br Med J (Clin Res Ed) 1984; 289 doi: https://doi.org/10.1136/bmj.289.6447.717 (Published 22 September 1984) Cite this as: Br Med J (Clin Res Ed) 1984;289:717
- B K Sharma,
- I A Santana,
- E C Wood,
- R P Walt,
- M Pereira,
- P Noone,
- P L Smith,
- C L Walters,
- R E Pounder
Abstract
Ten healthy volunteers were studied before, during, and after treatment with omeprazole 30 mg daily for two weeks. On the 14th night mean nocturnal (2100-0700) intragastric acidity was significantly decreased by 75% (p less than 0.001). At 0700, 22 hours after the last dose of omeprazole, there were significant increases in the bacterial count and the nitrite and N-nitrosamine concentrations in the gastric juice (p less than 0.001). Three days later these changes had resolved. Short term treatment of healthy volunteers with omeprazole is associated with a short lived increase in the gastric bacterial flora, with endogenous production of N-nitroso compounds.