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Generic methodological issues
A systematic review of symptomatic outcomes used in oesophagitis drug therapy trials
  1. N Sharma1,
  2. C Donnellan2,
  3. C Preston2,
  4. B Delaney3,
  5. G Duckett1,
  6. P Moayyedi1,3
  1. 1Gastroenterology Unit, City Hospital, Dudley Road, Winson Green, Birmingham, UK
  2. 2Centre for Digestive Diseases, The General Infirmary at Leeds, Great George Street, Leeds, UK
  3. 3Primary Care Clinical Sciences Building, University of Birmingham, Birmingham, UK
  1. Correspondence to:
    Professor P Moayyedi
    Gastroenterology Division, McMaster University-HSC 4W8, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5; evanslmcmaster.ca

Abstract

Symptoms are an important outcome for measurement in clinical trials into gastro-oesophageal reflux disease, but the optimal approach to symptom assessment has not been formally evaluated. The authors conducted a systematic review to assess how reflux symptoms have been evaluated and how well these correlate with oesophagitis healing and relapse.

  • gastro-oesophageal reflux disease
  • healing of oesophagitis
  • heartburn
  • symptom frequency
  • symptom severity
  • GORD, gastro-oesophageal reflux disease
  • PGWBI, psychological general well being index
  • SF-36, short form 36

https://doi.org/10.1136/gut.2003.034371

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