BMJ gastroenterology COVID-19 collection

This collection of articles highlights all research relating to the COVID-19 pandemic published by Gut, Frontline Gastroenterology and BMJ Open Gastroenterology. It will continue to grow as new articles are published. In the current climate, it is vital that research into the disease is as accessible as possible for clinicians, healthcare workers and researchers across the globe. We hope that this collection of research into COVID-19 and gastroenterology will be a useful resource. To explore more research, news, opinion pieces and resources published by The BMJ and all BMJ Journals, visit BMJ’s Coronavirus Hub. For the latest updates on research published by the journals and guidance from the British Society of Gastroenterology, be sure to follow @Gut_BMJ, @FrontGastro_BMJ , @BMJOpen_Gastro and @BritSocGastro on Twitter.

Jump to: COVID-19 Clinical COVID-19 IBD COVID-19 Endoscopy COVID-19 Basic Science COVID-19 Epidemiology COVID-19 GI Service COVID-19 Hepatology

COVID-19 Clinical

Diarrhoea may be underestimated: a missing link in 2019 novel coronavirus Gut, 26th February 2020, Letter SARS-CoV-2 induced diarrhoea as onset symptom in patient with COVID-19 Gut, 5th February 2020, Letter COVID-19 in gastroenterology: a clinical perspective Gut, 20th March 2020, Letter COVID-19 and the gastrointestinal tract: more than meets the eye Gut, 9th April 2020, Commentary Gastrointestinal Symptoms of 95 Cases with SARS-CoV-2 Infection Gut, 2nd April 2020, Original Research Faecal calprotectin indicates intestinal inflammation in COVID-19 Gut, 20th April 2020, Letter COVID-19 and the gastrointestinal tract: emerging clinical data Frontline Gastroenterology, 27th April 2020, Review Severe liver failure during SARS-CoV-2 infection Gut, 23rd April 2020, Letter COVID-19 guidance in chronic diseases: a need to reach across the borders of the traditional medical specialities Frontline Gastroenterology, 7th May 2020, Letter GI symptoms as early signs of COVID-19 in hospitalised Italian patients Gut, 14th May 2020, Letter The price of being a doctor during the COVID-19 outbreak Gut, 10th May 2020, Letter Comparative study of the clinical characteristics and epidemiological trend of 244 COVID-19 infected children with or without GI symptoms Gut, 19th May 2020, Letter Clinical course and risk factors for mortality of COVID-19 patients with pre-existing cirrhosis: a multicentre cohort study Gut, 20th May 2020, Letter Novelty in the gut: a systematic review and meta-analysis of the gastrointestinal manifestations of COVID-19 BMJ Open Gastroenterology, 25th May 2020, Gastrointestinal Infection Prevalence, risk factors and clinical outcomes of COVID-19 in patients with a history of pancreatitis in Northern California Gut, 3rd June 2020, Letter Pneumatosis intestinalis in COVID-19 BMJ Open Gastroenterology, 9th June 2020, Case Report Risk factors in patients with COVID-19 developing severe liver injury during hospitalisation Gut, 22nd June 2020, Letter GI symptoms and fever increase the risk of severe illness and death in patients with COVID-19 Gut, 30th June 2020, Letter Reorganisation of faecal microbiota transplant services during the COVID-19 pandemic Gut, 3rd July 2020, Guidelines Alteration of taste or smell as a predictor of COVID-19 Gut, 3rd July 2020, Letter COVID-19 and the gastrointestinal tract: recent data Frontline Gastroenterology, 5th July 2020, Education Depicting SARS-CoV-2 faecal viral activity in association with gut microbiota composition in patients with COVID-19 Gut, 20th July 2020, Original Research Severe clinical outcomes of COVID-19 associated with proton pump inhibitors: a nationwide cohort study with propensity score matching Gut, 30th July 2020, Gastroduodenal Gastrointestinal manifestations of COVID-19 in children: a systematic review and meta-analysis Frontline Gastroenterology, 18th August 2020, Education A nationwide cohort study with propensity score matching Gut, 9th October 2020, Letter Proton pump inhibitor or famotidine use and severe COVID-19 disease: a propensity score-matched territory wide study Gut, 4th December 2020, Letter Proton pump inhibitors and the risk of severe COVID-19: a post-hoc analysis from the Korean nationwide cohort Gut, 10th December 2020, Letter Aerosol generation and droplet spread during nasogastric intubation in the COVID-19 era Gut, 31st December 2020, Letter Serotonin is elevated in COVID-19-associated diarrhoea Gut, 5th January 2021, Letter The value of anal swab RT-PCR for COVID-19 diagnosis in adult Indonesian patients BMJ Open Gastroenterology, 19th May 2021, Infection Residual SARS-CoV-2 viral antigens detected in GI and hepatic tissues from five recovered patients with COVID-19 Gut, 2nd June 2021, Letter Duality of the association between COVID-19 and acute pancreatitis Gut, 3rd June 2021, Letter Acute-on-chronic liver failure (ACLF) precipitated by severe alcoholic hepatitis: another collateral damage of the COVID-19 pandemic? Gut, 17th June 2021, Letter Identification of the source events for aerosol generation during oesophago-gastro-duodenoscopy Gut, 29th June 2021, Original Research Rapid resolution of COVID-19 after faecal microbiota transplantation Gut, 6th July 2021, Letter Comparison between non-pulmonary and pulmonary immune responses in a HIV decedent who succumbed to COVID-19 Gut, 10th August 2021, Letter Diet quality and risk and severity of COVID-19: a prospective cohort study Gut, 6th September 2021, COVID-19 Incidence of ‘new-onset’ constipation and associated factors during lockdown due to the COVID-19 pandemic BMJ Open Gastroenterology, 16th September 2021, Motility Proton-pump inhibitor use is not associated with severe COVID-19-related outcomes: a propensity score weighted analysis of a national veteran cohort Gut, 18th October 2021, Letter Prevalence and outcomes of acute pancreatitis in COVID-19: a meta-analysis Gut, 20th October 2021, Letter SARS-CoV-2 infection is associated with an increased risk of idiopathic acute pancreatitis but not pancreatic exocrine insufficiency or diabetes: long-term results of the COVIDPAN study Gut, 11th November 2021, Letter Clinical characteristics, hospitalisation and mortality rates of COVID-19 among patients with coeliac disease in the USA: a multicentre network study Gut, 11th November 2021, Letter

COVID-19 IBD

A fatal case of COVID-19 pneumonia occurring in a patient with severe acute ulcerative colitis Gut, 3rd March 2020, Letter An urgent need to institute COVID-19 testing in patients with IBD experiencing flares Frontline Gastroenterology, 27th March 2020, Opinion Covid-19 and immunomodulation in IBD Gut, 17th April 2020, Recent advances in basic science British Society of Gastroenterology guidance for management of inflammatory bowel disease during the COVID-19 pandemic Gut, 17th April 2020, Guidelines Covid-19 infection in Crohn’s disease under treatment with adalimumab Gut, 20th April 2020, Letter Outcomes of COVID-19 in 79 patients with IBD in Italy: an IG-IBD study Gut, 30th April 2020, Original Research Adaptations to the British Society of Gastroenterology guidelines on the management of acute severe UC in the context of the COVID-19 pandemic: a RAND appropriateness panel Gut, 8th June 2020, Original Research Organisational changes and challenges for inflammatory bowel disease services in the UK during the COVID-19 pandemic Frontline Gastroenterology, 16th June 2020, Original Research Infliximab for severe ulcerative colitis and subsequent SARS-CoV-2 pneumonia: a stone for two birds Gut, 17th June 2020, Letter Implications of recurrent SARS-CoV-2 outbreaks for IBD management Frontline Gastroenterology, 24th June 2020, Review Adaptations to the current ECCO/ESPGHAN guidelines on the management of paediatric acute severe colitis in the context of the COVID-19 pandemic: a RAND appropriateness panel Gut, 1st September 2020, Original Article COVID-19-related health anxieties and impact of specific interventions in patients with inflammatory bowel disease in the UK Frontline Gastroenterology, 11th September 2020, Original Research Effect of IBD medications on COVID-19 outcomes: results from an international registry Gut, 20th October 2020, Original Research Disease monitoring of biologic treatment in IBD: early impact and future implications of COVID-19 pandemic Frontline Gastroenterology, 30th September 2020, Opinion Life in lockdown: experiences of patients with IBD during COVID-19 BMJ Open Gastroenterology, 19th November 2020, IBD COVID-19 and IBD drugs: should we change anything at the moment? Gut, 19th November 2020, Commentary Maintenance therapy with infliximab or vedolizumab in IBD is not associated with increased SARS-CoV-2 seroprevalence: UK experience in the 2020 pandemic Gut, 12th February 2021, Letter Depression, anxiety and stress among patients with inflammatory bowel disease during the COVID-19 pandemic: Australian national survey BMJ Open Gastroenterology, 12th February 2021, IBD COVID-19: impetus to the adoption of capsule endoscopy as a primary diagnostic tool? Frontline Gastroenterology, 24th February 2021, Commentary Association between 5-aminosalicylates in patients with IBD and risk of severe COVID-19: an artefactual result of research methodology? Gut, 3rd March 2021, Letter Risk factors for SARS-CoV-2 infection and course of COVID-19 disease in patients with IBD in the Veterans Affair Healthcare System Gut, 22nd March 2021, Original Research Anti-SARS-CoV-2 antibody responses are attenuated in patients with IBD treated with infliximab Gut, 7th April 2021, Original Research Infliximab is associated with attenuated immunogenicity to BNT162b2 and ChAdOx1 nCoV-19 SARS-CoV-2 vaccines in patients with IBD Gut, 26th April 2021, Original Research Point-of-care faecal calprotectin testing in patients with paediatric inflammatory bowel disease during the COVID-19 pandemic BMJ Open Gastroenterology, 4th May 2021, IBD Antibody response to SARS-CoV-2 among individuals with IBD diminishes over time: a serosurveillance cohort study Gut, 2nd August 2021, Letter Quality of life in patients with IBD during the COVID-19 pandemic in the Netherlands BMJ Open Gastroenterology, 2nd July 2021, IBD Impact of medical therapies for inflammatory bowel disease on the severity of COVID-19: a systematic review and meta-analysis BMJ Open Gastroenterology, 1st November 2021, IBD

COVID-19 Endoscopy

Practice of Endoscopy during COVID-19 Pandemic: Position Statements of Asian Pacific Society of Digestive Endoscopy (APSDE-COVID Statements) Gut, 2nd April 2020, Guidelines The prevention of nosocomial SARS-CoV2 transmission in endoscopy: international recommendations and the need for a gold standard. Gut, 2nd April 2020, Letter Gastrointestinal endoscopy during COVID-19: when less is more Frontline Gastroenterology, 15th April 2020, Commentary Low risk of covid-19 transmission in GI endoscopy Gut, 22nd April 2020, Endoscopy News APSDE-COVID statements: recommendations should be modified according to the prevalence of COVID infection rates Gut, 30th April 2020, Letter Safely restarting GI endoscopy in the era of COVID-19 Gut, 5th June 2020, Leading Article Impact of the COVID-19 outbreak on endoscopy training in a tertiary care centre in Germany Frontline Gastroenterology, 10th June 2020, Education COVID-19 and endoscopy training Frontline Gastroenterology, 10th June 2020, Letter Development and evaluation of a novel protective device for upper gastrointestinal endoscopy in the COVID-19 pandemic: the EBOX Frontline Gastroenterology, 12th June 2020, Original Research Data from a large Western centre exploring the impact of COVID-19 pandemic on endoscopy services and cancer diagnosis Frontline Gastroenterology, 20th July 2020, Original Research Protective enclosure for performing gastrointestinal endoscopy Frontline Gastroenterology, 4th August 2020, Letter Multicentre prospective study of COVID-19 transmission following outpatient GI endoscopy in the UK Gut, 14th September 2020, Endoscopy News Effects of SARS-CoV-2 emergency measures on high-risk lesions detection: a multicentre cross-sectional study Gut, 28th September 2020, Endoscopy News Clinical, financial and academic implications of COVID-19 on a tertiary care interventional endoscopy programme Gut, 14th December 2020, Endoscopy News Endoscopes used in positive and critically ill patients are SARS-CoV-2 negative at virological assessment Gut, 6th January 2021, Endoscopy News Adherence to recommendations for endoscopy practice during COVID-19 pandemic in Latin America: how are we doing it? BMJ Open Gastroenterology, 12th January 2021, Endoscopy Endoscopy training in the UK pre-COVID–19 environment: a multidisciplinary survey of endoscopy training and the experience of reciprocal feedback Frontline Gastroenterology, 7th February 2021, Original Research SARS-CoV-2 transmission via endoscopy in the COVID-19 era Gut, 5th March 2021, Letter COVID-19 transmission following outpatient endoscopy during pandemic acceleration phase involving SARS-CoV-2 VOC 202012/01 variant in UK Gut, 24th March 2021, Endoscopy News SARS-CoV-2 in endoscopy: a potential way of microorganisms’ air transmission Gut, 5th May 2021, Letter SARS-COV-2 in endoscopy: still a long way to go Gut, 11th June 2021, Letter Haemorrhagic ulcerative duodenitis in a patient with COVID-19 infection: clinical improvement following treatment with budesonide BMJ Open Gastroenterology, 18th October 2021, Endoscopy

COVID-19 Basic Science

Digestive system is a potential route of COVID-19: an analysis of single-cell co-expression pattern of key proteins in viral entry process Gut, 2nd April 2020, Original Research Alterations in the human oral and gut microbiomes and lipidomics in COVID-19 Gut, 31st March 2021, Original Research Enhanced donor screening for faecal microbial transplantation during COVID-19 Gut, 31st March 2021, Letter Six-month follow-up of gut microbiota richness in patients with COVID-19 Gut, 8th April 2021, Letter Gut as viral reservoir: lessons from gut viromes, HIV and COVID-19 Gut, 26th April 2021, Leading Article

COVID-19 Epidemiology

Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms Gut, 23rd March 2020, Original Research Famotidine use and quantitative symptom tracking for COVID-19 in non-hospitalised patients: a case series Gut, 4th June 2020, Gastroduodenal Gastroenterological and hepatic manifestations of patients with COVID-19, prevalence, mortality by country, and intensive care admission rate: systematic review and meta-analysis BMJ Open Gastroenterology, 4th March 2021, Epidemiology Diarrhoea and preadmission antibiotic exposure in COVID-19: a retrospective cohort study of 1153 hospitalised patients BMJ Open Gastroenterology, 6th September 2021, Epidemiology

COVID-19 GI Service

Gastroenterology department operational reorganisation at the time of covid-19 outbreak: an Italian and Chinese experience Gut, 16th April 2020, Leading Article Gastrointestinal cancer pathways may breakdown due to COVID-19 Frontline Gastroenterology, 11th June 2020, Letter Impact of the COVID-19 pandemic on UK endoscopic activity and cancer detection: a National Endoscopy Database Analysis Gut, 20th July 2020, Original Research Clinical research during the COVID-19 pandemic: gastroenterology researchers’ perspective Frontline Gastroenterology, 29th July 2020, Opinion Recovery of endoscopy services in the era of COVID-19: recommendations from an international Delphi consensus Gut, 14th August 2020, Guidelines COVID-19 and its impact on endoscopy services: what is the threshold for missed malignant diagnosis? Gut, 26th August 2020, Letter Prioritisation by FIT to mitigate the impact of delays in the 2-week wait colorectal cancer referral pathway during the COVID-19 pandemic: a UK modelling study Gut, 27th August 2020, Original Research Triage guidance for upper gastrointestinal physiology investigations during restoration of services during the COVID-19 pandemic Frontline Gastroenterology, 30th September 2020, Opinion Exit strategies from the COVID-19 lockdown for children and young people receiving home parenteral nutrition (HPN): lessons from the BSPGHAN Intestinal Failure Working Group experience Frontline Gastroenterology, 27th October 2020, Opinion Mandatory preprocedure testing for SARS-CoV-2 for all-comers may not be required for resuming endoscopic services amidst the ongoing COVID-19 pandemic Gut, 6th November 2020, Letter Impact of COVID-19 pandemic on key performance indicators in pancreatobiliary endoscopy: prioritise, minimise risk, keep scoping and training Frontline Gastroenterology, 15th December 2020, Original Research COVID-19 and endoscopic services: the impact of delays in therapeutic colonoscopies on patients Gut, 4th February 2021, Letter Gastroenterology 2021: from the heart of the COVID-19 pandemic Frontline Gastroenterology, 5th February 2021, Opinion

COVID-19 Hepatology

Risk of severe illness from COVID-19 in patients with metabolic dysfunction-associated fatty liver disease and increased fibrosis Gut, 15th May 2020, Letter Prioritisation and the initiation of HCC surveillance in CHB patients: lessons to learn from the COVID-19 crisis Gut, 25th May 2020, Leading Article One world, one pandemic, many guidelines: management of liver diseases during COVID-19 Gut, 4th June, Leading Article COVID-19 in an international European liver transplant recipient cohort Gut, 22nd June 2020, Original Research Liver injury is independently associated with adverse clinical outcomes in patients with COVID-19 Gut, 8th July 2020, Original Research Comparison of mortality risk in patients with cirrhosis and COVID-19 compared with patients with cirrhosis alone and COVID-19 alone: multicentre matched cohort Gut, 13th July 2020, Original Research Involvement of liver in COVID-19: systematic review and meta-analysis Gut, 15th July 2020, Letter Liver stiffness by transient elastography accompanies illness severity in COVID-19 BMJ Open Gastroenterology, 13th July 2020, Hepatology Modulating immunosuppression in liver transplant patients with COVID-19 Gut, 18th August 2020, Letter COVID-19 in patients with cirrhosis: understanding adverse impact Gut, 21st August 2020, Letter Combination of CLIF-OF and CCI predicts survival in patients with cirrhosis and COVID-19 Gut, 7th October 2020, Letter Severe alcohol-related liver disease admissions post-COVID-19 lockdown: canary in the coal mine? Frontline Gastroenterology, 26th October 2020, Letter Abnormal liver blood tests among hospitalised patients with SARS-CoV2 (COVID-19) Frontline Gastroenterology, 2nd November 2020, Commentary Liver dysfunction in COVID-19: a useful prognostic marker of severe disease? Frontline Gastroenterology, 22nd December 2020, Original Research Liver function test abnormalities at hospital admission are associated with severe course of SARS-CoV-2 infection: a prospective cohort study Gut, 29th January 2021, Original Research Liver injury, hypoalbuminaemia and severe SARS-CoV-2 infection Gut, 2nd June 2021, Letter Exercising in the COVID-19 era: implications in non-alcoholic fatty liver disease (NAFLD) BMJ Open Gastroenterology, 24th June 2021, Communication COVID-19 in liver transplant candidates: pretransplant and post-transplant outcomes – an ELITA/ELTR multicentre cohort study Gut, 19th July 2021, Hepatology Challenges of continuation of live liver donor programme during COVID-19 pandemic in Pakistan: outcomes and lessons learned BMJ Open Gastroenterology, 20th October 2021, Hepatology Clinical outcomes in COVID-19 and cirrhosis: a systematic review and meta-analysis of observational studies BMJ Open Gastroenterology, 21st October 2021, Hepatology