Top Cited Articles

We wanted to highlight our top cited research from the past 3 years to draw attention to the high quality, cutting edge research and reviews in the field of Gastroenterology and Hepatology. As a thank you to our authors and readers, we have made these articles free to access.


Long-term proton pump inhibitors and risk of gastric cancer development after treatment for Helicobacter pylori: a population-based study
Ka Shing Cheung, Esther W Chan, Angel Y. S. Wong, et al.

Interplay of host genetics and gut microbiota underlying the onset and clinical presentation of inflammatory bowel disease
Floris Imhann, Arnau Vich Vila, Marc Jan Bonder, et al.

European evidence-based guidelines on pancreatic cystic neoplasms
Marco Del Chiaro, Marc G. Besselink, Lianne Scholten on behalf of The European Study Group on Cystic Tumours of the Pancreas et al.

Integrative analysis of exogenous, endogenous, tumour and immune factors for precision medicine
Shuji Ogino, Jonathan A. Nowak, Tsuyoshi Hamada, et al.

Human oral microbiome and prospective risk for pancreatic cancer: a population-based nested case-control study
Xiaozhou Fan, Alexander V. Alekseyenko, Jing Wu, et al.

Bacterial and fungal infections in acute-on-chronic liver failure: prevalence, characteristics and impact on prognosis
Javier Fernandez, Juan Acevedo, Reiner Wiest, et al.

Human gut microbiome: hopes, threats and promises
Patrice D. Cani

IL-6 and PD-L1 antibody blockade combination therapy reduces tumour progression in murine models of pancreatic cancer
Thomas A. Mace, Reena Shakya, Jason R. Pitarresi, et al.

Bacteriophage transfer during faecal microbiota transplantation in Clostridium difficile infection is associated with treatment outcome
Tao Zuo, Sunny H. Wong, Kelvin Lam, et al.

The oral microbiota in colorectal cancer is distinctive and predictive
Burkhardt Flemer, Ryan D. Warren, Maurice P. Barrett, et al.


Global patterns and trends in colorectal cancer incidence and mortality
Melina Arnold, Monica S. Sierra, Mathieu Laversanne, et al.

Management of Helicobacter pylori infection-the Maastricht V/Florence Consensus Report
P Malfertheiner, F Megraud, C. A. O’Morain on behalf of the European Helicobacter and Microbiota Study Group and Consensus panel, et al.

The safety of vedolizumab for ulcerative colitis and Crohn’s disease
Jean-Frederic Colombel, Bruce E. Sands, Paul Rutgeerts P, et al.

European consensus conference on faecal microbiota transplantation in clinical practice
Giovanni Cammarota, Gianluca Ianiro, Herbert Tilg, et al.

Fungal microbiota dysbiosis in IBD
Harry Sokol, Valentin Leducq, Hugues Aschard, et al.

Non-alcoholic fatty liver disease and its relationship with cardiovascular disease and other extrahepatic diseases
Leon A. Adams, Quentin M. Anstee, Herbert Tilg, et al.

Current and upcoming pharmacotherapy for non-alcoholic fatty liver disease
Yaron Rotman, Arun J. Sanyal

Tumour-associated and non-tumour-associated microbiota in colorectal cancer
Burkhardt Flemer, Denise B. Lynch, Jillian M. R. Brown, et al.

A microbial signature for Crohn’s disease
Victoria Pascal, Marta Pozuelo, Natalia Borruel, et al.

Acute-on-chronic liver failure: an update
Ruben Hernaez, Elsa Sola, Richard Moreau, et al.


The gut microbiota and host health: a new clinical frontier
Julian R. Marchesi, David H. Adams, Francesca Fava, et al.

Akkermansia muciniphila and improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology
Maria Carlota Dao, Amandine Everard, Judith Aron-Wisnewsky, et al.

Proton pump inhibitors affect the gut microbiome
Floris Imhann, Marc Jan Bonder, Arnau Vich Vila, et al.

High-level adherence to a Mediterranean diet beneficially impacts the gut microbiota and associated metabolome
Francesca De Filippis, Nicoletta Pellegrini, Lucia Vannini, et al.

Proton pump inhibitors alter the composition of the gut microbiota
Matthew A. Jackson, Julia K. Goodrich, Maria-Emanuela Maxan, et al.

Stool consistency is strongly associated with gut microbiota richness and composition, enterotypes and bacterial growth rates
Doris Vandeputte, Gwen Falony, Sara Viera-Silva, et al.

Proton pump inhibitor-responsive oesophageal eosinophilia: an entity challenging current diagnostic criteria for eosinophilic oesophagitis
Javier Molina-Infante, Albert J. Bredenoord, Edaire Cheng, et al.

Analysis of circulating tumour DNA to monitor disease burden following colorectal cancer surgery
Thomas Reinert, Lone V. Schøler, Rune Thomsen, et al.

Identification of an anti-inflammatory protein from Faecalibacterium prausnitzii, a commensal bacterium deficient in Crohn’s disease
E Quevrain, M A. Maubert, C Michon, et al.

Liver PPAR alpha is crucial for whole-body fatty acid homeostasis and is protective against NAFLD
Alexandra Montagner, Arnaud Polizzi, Edwin Fouche, et al.