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BCL10 nuclear expression and t(11;18)(q21;q21) indicate nonresponsiveness to Helicobacter pylori eradication of Chinese primary gastric MALT lymphoma

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Abstract

The eradication of Helicobacter pylori (H. pylori) with antibiotics induces complete remission in 75% of patients with gastric MALT lymphoma. We investigated the efficacy of H. pylori eradication and assessed the predictive value of BCL10 nuclear expression and t(11;18)(q21;q21) regarding resistance to H. pylori eradication in primary gastric mucosa-associated lymphoid tissue lymphoma (MALT lymphoma) patients from mainland China. Twenty-two gastric MALT cases (Stage IE) underwent H. pylori eradication with antibiotics, and sequential endoscopic-bioptic follow-ups were performed and assessed with regular morphologic and immunohistochemical examinations. BCL10 nuclear expression and interphase fluorescence in situ hybridization (FISH) for MALT1 and API2/MALT1 were tested. Thirteen out of the 22 cases (59.1%) achieved complete regression (CR) after the eradication of H. pylori. The longest follow-up period in the 22 patients was 68 months, with 12 patients longer than 24 months. For the 13 CR patients, the longest follow-up period after H. pylori eradication was 53 months, with 6 patients longer than 24 months. BCL10 nuclear expression was detected by immunohistochemical staining in 9 cases, including 7 (77.8%) of 9 cases who showed no response (NR) and 2 (15.4%) of 13 patients who achieved CR following eradication therapy (P < 0.05). t(11;18)(q21;q21) was evaluated by interphase FISH in 18 cases including 11 CR and 7 NR patients after H. pylori eradication. t(11;18)(q21;q21) was found in 4 (57.1%) of 7 patients who showed NR following H. pylori eradication, but one in 11 CR patients (P < 0.05). A total of 59.1% of patients with early gastric MALT lymphoma recruited in this study achieved CR after H. pylori eradication. BCL10 nuclear expression and t(11;18)(q21;q21)-positive gastric MALT lymphomas are likely to be related to a failure to respond to H. pylori eradication in Chinese patients.

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Acknowledgments

This study was supported by the National Natural Science Fundation of China (30428018) and Natural Science Fundation of Guangxi Zhuang Autonomous Region (0499015). We thank Professor Ming-Qing Du, Division of Molecular Histopathology, Department of Pathology, University of Cambridge, UK, for his technical assistance.

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Authors and Affiliations

  1. Department of Pathology, Peking University Health Science Center, 100191, Beijing, People’s Republic of China

    Gehong Dong, Cuiling Liu, Jie Zheng, Min Li, Xin Huang, Yuanjie Huang, Yunfei Shi, Wenjuan Yin & Zifen Gao

  2. Division of Molecular Histopathology, Department of Pathology, University of Cambridge, Cambridge, UK

    Hongtao Ye

  3. Department of Pathology, Guilin Medical College, 541004, Guilin, People’s Republic of China

    Hongtao Ye

  4. Department of Pathology, Capital Medical University, 100069, Beijing, People’s Republic of China

    Liping Gong

  5. Department of Digestive Disease, Peking University Third Hospital, 100191, Beijing, People’s Republic of China

    Xuebiao Huang

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  1. Gehong Dong
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  2. Cuiling Liu
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  3. Hongtao Ye
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  6. Min Li
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  7. Xin Huang
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  9. Yuanjie Huang
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  11. Wenjuan Yin
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  12. Zifen Gao
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Correspondence to Zifen Gao.

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Both G. Dong and C. Liu are treated as co-first authors.

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Dong, G., Liu, C., Ye, H. et al. BCL10 nuclear expression and t(11;18)(q21;q21) indicate nonresponsiveness to Helicobacter pylori eradication of Chinese primary gastric MALT lymphoma. Int J Hematol 88, 516–523 (2008). https://doi.org/10.1007/s12185-008-0187-z

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  • DOI: https://doi.org/10.1007/s12185-008-0187-z

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