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Hyperplasia of oligodendrocytes in quaking mice

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Summary

The number of neuroglial cells in selected fiber tracts of 90-day-old quaking and normal mice was determined by a combination of light and electron microscopy. Oligodendrocytes of quaking mice are normal in number in the anterior commissure and corticospinal tract (in the cervical spinal cord) but are increased two- to fourfold in the optic nerve and the fasciculi cuneatus and gracilis (in the cervical spinal cord). The nuclei and perikarya are normal in size or smaller than normal.

Those tracts with the greatest hyperplasia of oligodendrocytes also have the greatest conten of myelin, suggesting that cell number influences content of myelin. However, the volume of myelin per oligodendrocyte also varies, between 2 and 11% of normal, in the different tracts of the mutant.

The hyperplasia of oligodendrocytes in quaking mice may arise as compensation for their decreased production of myelin and reflect a normal plasticity in the processes of myelination. If so, the mutant may be a useful system for study of the regulation of myelogenesis.

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Authors and Affiliations

  1. Department of Anatomy, Harvard Medical School, Boston, Mass., USA

    Victor L. Friedrich Jr.

  2. Department of Biobehavioral Sciences, The University of Connecticut, Storrs, Conn., USA

    Victor L. Friedrich Jr.

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  1. Victor L. Friedrich Jr.
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Supported by Training Grant MH-07084 and Research Grants NS-03659 and NS-09904 from the U.S. Public Health Service and Training Grant NS-05591 from the National Institute of Neurological and Communicative Diseases and Stroke. This work was submitted to Harvard University in partial fulfillment of requirements for the degree of Doctor of Philosophy. I am indebted to Dr. S. L. Palay for his generous support and guidance.

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Friedrich, V.L. Hyperplasia of oligodendrocytes in quaking mice. Anat. Embryol. 147, 259–271 (1975). https://doi.org/10.1007/BF00315075

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