Abstract
The sensitivity and specificity of the pancreolauryl test was evaluated in comparison with the NBT-PABA test, the estimation of fecal chymotrypsin and fat, and the secretinpancreozymin test in 168 patients with and without pancreatic disease. The overall sensitivity rate was as follows: pancreolauryl test 90%, NBT-PABA test 86%, fecal chymotrypsin 66%. In patients with pancreatic steatorrhea the sensitivity of the pancreolauryl test was 100%, the NBT-PABA test 97%, and the fecal chymotrypsin estimation 92%. The specificity of these tests was: pancreolauryl test 97.6%, fecal chymotrypsin 87%, and NBT-PABA test 81.8%. The pancreolauryl test may be recommended as a noninvasive easy-to-perform tubeless pancreatic function test with a sufficiently high sensitivity and specificity.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Editorial: Diagnosis of chronic pancreatitis. Lancet 1:719–720, 1982
Braganza JM, Hunt LP, Warwick F: Relationship between pancreatic exocrine function and ductal morphology in chronic pancreatitis. Gastroenterology 82:1341–1347, 1982
Lankisch PG: Tubeless pancreatic function tests. Hepato-Gastroenterology 28:333–338, 1981
Lankisch PG: Progress report: Exocrine pancreatic function tests. Gut 23:777–798, 1982
Kaffarnik H, Meyer-Bertenrath JG: Zur Methodik und klinischen Bedeutung eines neuen Pankreaslipase-Tests mit Fluoresceindilaurinsäureester. Klin Wochenschr 47:221–223, 1969
Kaffarnik H, Klimkeit P, Zöfel P, Otte U, Meyer-Bertenrath JG: Zur Klinischen Wertigkeit des oralen Pankreasfunktions-tests mit Fluoreszein-Dilaurat. Münch Med Wochenschr 119:1467–1470, 1977
Lankisch PG, Ehrhardt-Schmelzer S, Koop H, Caspary WF: Der NBT-PABA-Test in der Diagnostik der exokrinen Pankreasinsuffizienz. Ein Vergleich mit dem Sekretin-Pankreozymin-Test, den Stuhlenzym-Bestimmungen und der quantitativen Stuhlfett-Analyse. Dtsch Med Wochenschr 105:1418–1423, 1980
Ammann R: Fortschritte in der Pankreasfunktionsdiagnostik. Berlin: Springer, 1967
Kamer JH van de, Bockel H ten, Weijers HA: Rapid method for the determination of fat in feces. J Biol Chem 177:347–355, 1949
Creutzfeldt W: Funktionsdiagnostik bei Erkrankungen des exokrinen Pankreas. Verh Dtsch Ges Inn Med 70:781–801, 1964
Mitchell CJ, Humphrey CS, Bullen AW, Kelleher J, Losowsky MS: Improved diagnostic accuracy of a modified oral pancreatic function test. Scand J Gastroenterol 14:737–741, 1979
Kay G, Hine P, Braganza J: The pancreolauryl test. A method of assessing the combined functional efficacy of pancreatic esterase and bile saltsin vivo? Digestion 24:241–245, 1982
Stock KP, Schenk J, Schmack B, Domschke W: Funktions-“Screening” des exokrinen Pankreas. FDL-, N-BT-PABA-Test, Stuhl-Chymotrypsinbestimmung im Vergleich mit dem Sekretin-Pankreozymin-Test. Dtsch Med Wochenschr 106:983–987, 1981
Caspary WF, Elsenhans B, Graf S, Lankisch PG, Creutzfeldt W: Intestinale Resorption des synthetischen TripeptidsN-Benzoyl-l-Tyrosyl-p-Aminobenzoesäure (PABA). Z Gastroenterol 9:611, 1979 (abstract)
Yamato Ch, Konoshita K: Hydrolysis and metabolism ofN-Benzoyl-l-tyrosyl-p-aminobenzoic acid in normal and pancreatic duct-ligated animals. J Pharmacol Exp Ther 206:468–474, 1978
Meyer-Bertenrath JG: Personal communication.
Gyr K, Felsenfeld O, Imondi AR: Chymotrypsin-like activity of some intestinal bacteria. Am J Dig Dis 23:413–416, 1978
Schönberger W, Weitzel D: Diagnose der exokrinen Pankreasinsuffizienz mit Fluorescein-Dilaurat bei Patienten mit cystischer Fibrose. Mschr Kinderheilkd 128:195–198, 1980
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Lankisch, P.G., Schreiber, A. & Otto, J. Pancreolauryl test. Digest Dis Sci 28, 490–493 (1983). https://doi.org/10.1007/BF01308149
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01308149