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Research Article
Family occurrence of achalasia and diffuse spasm of the oesophagus.
  1. T Frieling,
  2. W Berges,
  3. F Borchard,
  4. H J Lübke,
  5. P Enck,
  6. M Wienbeck
  1. Department of Gastroenterology, University of Düsseldorf, FR Germany.

    Abstract

    In view of the unknown aetiology of achalasia and diffuse oesophageal spasm we report four families (father/son, mother/son, brother/brother, cousin/cousin) with achalasia and oesophageal spasm examined by radiology, endoscopy and manometry. Family occurrence of oesophageal motor disorders supports the hypothesis that a genetic trait may play a role in the pathogenesis. The family coincidence of achalasia and oesophageal spasm supports a close relationship between the two diseases.

    https://doi.org/10.1136/gut.29.11.1595

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