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The role of gender on clearance of hepatitis C virus: a different story in an area endemic for hepatitis B and C
  1. Chia-Yen Dai1,
  2. Jee-Fu Huang2,
  3. Ming-Yen Hsieh2,
  4. Li-Po Lee2,
  5. Chi-Kung Ho3,
  6. Wan-Long Chuang4,
  7. Ming-Lung Yu5
  1. 1Department of Occupational Medicine, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung, Taiwan
  2. 2Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
  3. 3Department of Occupational Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
  4. 4Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
  5. 5Faculty of Internal Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
  1. Correspondence to:
    Dr M-L Yu
    Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, No 100, Tzyou 1st Road, Kaohsiung 807, Taiwan; d820195{at}gmail.com

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We read with interest the article by Bakr et al (GUT 2006;55:1183–7). The authors recruited 4720 residents aged 18–65 years from a rural community in Egypt, a country hyperendemic for hepatitis C virus (HCV) infection, which might be attributed to mass campaigns for intravenous antischistosomal treatment.1 They found that the HCV antibody (anti-HCV) was positive in 910 individuals (19.3%), and 38.5% of the anti-HCV-positive individuals were negative for serum HCV RNA. Interestingly, the authors concluded that women had a significantly higher HCV clearance rate (44.6% vs 33.7%, respectively; p = 0.001, adjusted OR 1.77) than men, which was similar to reports by Inoue et al2 and Yamakawa et al3 from Japan.

We conducted a large-scale community-based study in southern Taiwan, a country hyperendemic for hepatitis B virus (HBV) …

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