Footnotes

• Twitter @manuelefurnari, @ivoboskoski

• Collaborators The Young-ENDO-ITA Study Group: Stefano Angeletti; Federico Barbaro; Matteo Brunacci; Maria Cazzato; Vito Domenico Corleto; Maria Giulia Demarzo; Elisa Giambruno; Gaetano Morreale; Alessandro Moscatelli; Mario Pesenti; Lino Polese; Davide Risso; Giacomo Tamanini; and Fabiana Zingone.

• Contributors MF, ES, LHE and GE conceived the study and wrote the manuscript. IB and EGG designed the study and wrote the manuscript. AB, EDG, AM, MDB, MGD, EG, GT and MC acquired data. FZ, LP, SA, VDC, MP and FB created and managed the database, searched literature and revised final manuscript. DR, CP, SP and MM analysed data. CS, LR and GC designed and revised the manuscript. All members of the Young-ENDO-ITA Study Group Study Group extracted and collected the data for each centre. All authors critically read and intellectually contributed to the manuscript.

• Funding Personal funding to declare: Foundation for Cancer Research (AIRC) IG 21723 (to LR).

• Competing interests Beyond the conduction of this study, IB declares to be: consultant for Apollo Endosurgery, Cook Medical and Boston Scientific; board member for Endo Tools; research grant recipient from Apollo Endosurgery; GC declares to be: consultant for and food and beverage compensation from Cook Medical, Boston Scientific and Olympus; ES declares to be: lecturer or consultant for Takeda, Janssen, Abbvie, MSD, Sofar, Malesci, Sandoz, Reckitt Benckiser and Medtronic; board member for Frasenius Kabi and BMS; research grant recipient from Unifarco, Sila and Sofar.

• Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research.

• Provenance and peer review Not commissioned; internally peer reviewed.