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Inflammatory bowel disease
PTU-076 Diagnostic Potential of Volatile Organic Compounds as Faecal Biomarkers in Inflammatory Bowel Disease
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  1. H Jayasena1,
  2. T Khalid2,
  3. C S Probert3
  1. 1Gastroenterology, Bristol Royal Infirmary, Bristol
  2. 2University of Liverpool, Liverpool, UK
  3. 3Institute of Tanslational Medicine, University of Liverpool, Liverpool, UK

Abstract

Introduction VOCs can be utilised as non invasive biomarkers for gastrointestinal diseases such as IBD, as changes in VOCs reflect internal metabolical and pathological processes.

Methods Patients were recruited from outpatients with proven Crohn’s disease(CD N = 41), ulcerative colitis(UC N = 49), IBS(N = 30) and healthy volunteers(N = 47). Disease activity was recorded using Harvey-Bradshaw index(HBI) in CD and simple clinical colitis activity index(SCCAI) in UC. Faecal headspace gas was sampled with SPME and transferred to GC-MS for VOC identification. Statistical analysis was performed on presence or absence and peak area of VOCs.

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Results ConclusionFaecal VOCs are capable of distinguishing IBD from non-inflammatory conditions like IBS and healthy.

Disclosure of Interest None Declared

https://doi.org/10.1136/gutjnl-2013-304907.168

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